Please use this identifier to cite or link to this item: https://doi.org/10.1142/S0129183107009273
DC FieldValue
dc.titleNumerical study on the influence of surface roughness on fluid flow and mass transfer in a flat-plate microchannel bioreactor
dc.contributor.authorZeng, Y.
dc.contributor.authorLee, T.-S.
dc.contributor.authorYu, P.
dc.contributor.authorLow, H.-T.
dc.date.accessioned2014-10-07T09:08:50Z
dc.date.available2014-10-07T09:08:50Z
dc.date.issued2007-02
dc.identifier.citationZeng, Y., Lee, T.-S., Yu, P., Low, H.-T. (2007-02). Numerical study on the influence of surface roughness on fluid flow and mass transfer in a flat-plate microchannel bioreactor. International Journal of Modern Physics C 18 (2) : 131-155. ScholarBank@NUS Repository. https://doi.org/10.1142/S0129183107009273
dc.identifier.issn01291831
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85509
dc.description.abstractSurface roughness exists in most microfluidic devices due to the microfabrication technique or particle adhesion. The present study has developed a numerical model based on Finite Volume Method to simulate the fluid flow and mass transfer in a flat-plate microchannel bioreactor with an array of rough elements uniformly placed on the bottom wall. Both semicircle and triangle roughness are considered to include more shapes of roughness elements. A monolayer of cells is assumed to attach to the base of the channels and consumes species from culture medium. The results show that the roughness size ratio (α) and the roughness distribution ratio (β) have direct and significant effects on fluid flow and mass transfer. The dimensionless parameters Peclet number (Pe) and Damkohler number (Da) can also influence mass transfer greatly. Although the two types of roughness have similar effects, at the same condition, the triangle roughness has larger effect on shear stress by showing higher dimensionless values at the channel base; the semicircle roughness has larger effect on mass transfer by showing lower dimensionless minimum base concentration (C̄min) and higher dimensionless absorption rate (Δj%). However, it is important to ensure the lower maximum shear stress and the adequate minimum species concentration for cell growth in rough channels. Hence, if the maximum shear stress and minimum concentration in rough channels can satisfy the critical conditions for cell growth, rough channels would be better than smooth channels because of their lower shear stress at the flat-bed part and higher mass transfer efficiency. The results would provide guidance on the flow and perfusion requirements to avoid shear stress damage and solute depletion or toxicity during cell culture. © World Scientific Publishing Company.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1142/S0129183107009273
dc.sourceScopus
dc.subjectFlat-plate microchannel bioreactor
dc.subjectFluid flow
dc.subjectMass transfer
dc.subjectNumerical modeling
dc.subjectSurface roughness
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.contributor.departmentTEMASEK LABORATORIES
dc.description.doi10.1142/S0129183107009273
dc.description.sourcetitleInternational Journal of Modern Physics C
dc.description.volume18
dc.description.issue2
dc.description.page131-155
dc.identifier.isiut000250954800001
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Dec 3, 2020

WEB OF SCIENCETM
Citations

1
checked on Nov 25, 2020

Page view(s)

79
checked on Nov 29, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.