Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2004.09.014
Title: Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers
Authors: Fujihara, K. 
Kotaki, M.
Ramakrishna, S. 
Keywords: Bone regeneration
Calcium carbonate
Cell adhesion
Nano-composite
Issue Date: Jul-2005
Citation: Fujihara, K., Kotaki, M., Ramakrishna, S. (2005-07). Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials 26 (19) : 4139-4147. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2004.09.014
Abstract: In this study, new type of guided bone regeneration (GBR) membranes were fabricated by polycaprolactone (PCL)/CaCO 3 composite nano-fibers with two different PCL to calcium carbonate (CaCO 3) ratios (PCL:CaCO 3=75:25 wt% and 25:75 wt%). The composite nano-fibers were successfully fabricated by electrospinning method and CaCO 3 nano-particles on the surface of nano-fibers were confirmed by energy disperse X-ray (EDX) analysis. In order to achieve mechanical stability of GBR membranes, composite nano-fibers were spun on PCL nano-fibrous membranes which has high tensile strength, i.e., the membranes consist of two layers of functional layer (PCL/CaCO 3) and mechanical support layer (PCL). Two different GBR membranes were prepared, i.e., GBR membrane (A)=PCL:CaCO 3=75:25 wt%+PCL, GBR membrane (B)=PCL:CaCO 3=25:75 wt%+PCL. Osteoblast attachment and proliferation of GBR membrane (A) and (B) were discussed by MTS assay and scanning electron microscope (SEM) observation. As a result, absorbance intensity of GBR membrane (A) and tissue culture polystyrene (TCPS) increased during 5 days seeding time. In contrast, although absorbance intensity of GBR membrane (B) also increased, its value was lower than membrane (A). SEM observation showed that no significant difference in osteoblast attachment manner was seen on GBR membrane (A) and (B). Because of good cell attachment manner, there is a potential to utilize PCL/CaCO 3 composite nano-fibers to GBR membranes. © 2004 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/85256
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2004.09.014
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

491
checked on Sep 18, 2019

WEB OF SCIENCETM
Citations

443
checked on Sep 18, 2019

Page view(s)

48
checked on Sep 7, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.