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Title: Fabrication and osteoregenerative application of composition-tunable CaCO3/HA composites
Authors: Yu, H.-D.
Zhang, Z.-Y. 
Win, K.Y.
Yu, H. 
Chan, J.K.Y.
Teoh, S.H. 
Han, M.-Y. 
Issue Date: 28-Mar-2011
Citation: Yu, H.-D., Zhang, Z.-Y., Win, K.Y., Yu, H., Chan, J.K.Y., Teoh, S.H., Han, M.-Y. (2011-03-28). Fabrication and osteoregenerative application of composition-tunable CaCO3/HA composites. Journal of Materials Chemistry 21 (12) : 4588-4592. ScholarBank@NUS Repository.
Abstract: A series of porous CaCO3/HA composites have been produced with an increased molar percentage of HA from 0, 10, 25, 50, 75 to 100%. The compression strength of the CaCO3/HA composites increases proportionally before reaching 50% and gradually levels off with a further increase up to 100%. The 50% CaCO3/HA composite, with a similar compression strength to natural bone, has been evaluated in vitro and in vivo, showing great potential for osteoregenerative applications. A three-step chemical process for preparing the CaCO3/HA composites has been revealed by time-dependent XRD analysis: (i) CaCO3 → CaO + CO2↑, (ii) 10CaO + 6(NH4)2HPO4 → Ca10(PO4)6(OH)2 + 12NH 3↑ + 8H2O↑, and (iii) CaO + CO2 → CaCO3/Ca(OH)2 + CO2 → CaCO 3 + H2O. The initial formation of porous CaO by a fast release of CO2 at high temperature leads to the production of the porous CaCO3/HA composites. Such understanding may allow us to extend this solid-phase fabrication approach to various other porous composites with controlled compositions for promising applications. © 2011 The Royal Society of Chemistry.
Source Title: Journal of Materials Chemistry
ISSN: 09599428
DOI: 10.1039/c0jm04161k
Appears in Collections:Staff Publications

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