Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijom.2013.05.008
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dc.titleEffects of scaffold architecture on cranial bone healing
dc.contributor.authorBerner, A.
dc.contributor.authorWoodruff, M.A.
dc.contributor.authorLam, C.X.F.
dc.contributor.authorArafat, M.T.
dc.contributor.authorSaifzadeh, S.
dc.contributor.authorSteck, R.
dc.contributor.authorRen, J.
dc.contributor.authorNerlich, M.
dc.contributor.authorEkaputra, A.K.
dc.contributor.authorGibson, I.
dc.contributor.authorHutmacher, D.W.
dc.date.accessioned2014-10-07T09:03:48Z
dc.date.available2014-10-07T09:03:48Z
dc.date.issued2014-04
dc.identifier.citationBerner, A., Woodruff, M.A., Lam, C.X.F., Arafat, M.T., Saifzadeh, S., Steck, R., Ren, J., Nerlich, M., Ekaputra, A.K., Gibson, I., Hutmacher, D.W. (2014-04). Effects of scaffold architecture on cranial bone healing. International Journal of Oral and Maxillofacial Surgery 43 (4) : 506-513. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijom.2013.05.008
dc.identifier.issn09015027
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/85085
dc.description.abstractIn the present study, polycaprolactone-tricalcium phosphate (PCL/TCP) scaffolds with two different fibre laydown patterns, which were coated with hydroxyapatite and gelatine, were used as an approach for optimizing bone regeneration in a critical-sized calvarial defect. After 12 weeks, bone regeneration was quantified using microcomputed tomography (micro-CT) analysis, biomechanical testing, and histological evaluation. Notably, the experimental groups with coated scaffolds showed lower bone formation and lower biomechanical properties within the defect compared to the uncoated scaffolds. Surprisingly, the different laydown pattern of the fibres resulted in different bone formation and biomechanical properties: the 0 /60 /120 scaffolds revealed lower bone formation and biomechanical properties compared to the 0 /90 scaffolds in all the experimental groups. Therefore, future bone regeneration strategies utilizing scaffolds should consider scaffold architecture as an important factor during the scaffold optimization stages in order to move closer to a clinical application. © 2013 International Association of Oral and Maxillofacial Surgeons.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.ijom.2013.05.008
dc.sourceScopus
dc.subjectbone tissue engineering
dc.subjectlaydown pattern
dc.subjectpolycaprolactone
dc.subjectrat skull defect
dc.subjectscaffolds
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.ijom.2013.05.008
dc.description.sourcetitleInternational Journal of Oral and Maxillofacial Surgery
dc.description.volume43
dc.description.issue4
dc.description.page506-513
dc.description.codenIJOSE
dc.identifier.isiut000333731000020
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