Please use this identifier to cite or link to this item: https://doi.org/10.1002/pi.2195
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dc.titleComparison of the degradation of polycaprolactone and polycaprolactone-(β-tricalcium phosphate) scaffolds in alkaline medium
dc.contributor.authorLam, C.X.F.
dc.contributor.authorTeoh, S.H.
dc.contributor.authorHutmacher, D.W.
dc.date.accessioned2014-10-07T09:01:56Z
dc.date.available2014-10-07T09:01:56Z
dc.date.issued2007-06
dc.identifier.citationLam, C.X.F., Teoh, S.H., Hutmacher, D.W. (2007-06). Comparison of the degradation of polycaprolactone and polycaprolactone-(β-tricalcium phosphate) scaffolds in alkaline medium. Polymer International 56 (6) : 718-728. ScholarBank@NUS Repository. https://doi.org/10.1002/pi.2195
dc.identifier.issn09598103
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/84927
dc.description.abstractThe design and fabrication of scaffolds and biodegradable devices using slow-degrading polymers and composites (degradation/resorption > 2 years) involve the necessity for long-term in vitro and in vivo studies. If multiple designs and materials need to be tested, then this would use much time and financial resources. Accelerated degradation systems aim to achieve comparable degradation profiles within a shorter period of time. This investigation considers the hydrolytic degradation of polycaprolactone (PCL) and PCL-calcium phosphate (CaP) scaffolds in 5 mol L-1 NaOH at 37°C. The scaffolds degrade via surface erosion, which proceeds in a consistent and predictable manner. The hydrolytic degradation of PCL-based scaffolds alone is slow, governed by their high molecular weights, crystallinity, hydrophobicity, surface-to-volume ratio and porosity. The incorporation of CaP significantly increases the degradation rate. © 2007 Society of Chemical Industry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/pi.2195
dc.sourceScopus
dc.subjectAlkaline medium
dc.subjectDegradation
dc.subjectPolycaprolactone
dc.subjectScaffolds
dc.subjectTricalcium phosphate composites
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1002/pi.2195
dc.description.sourcetitlePolymer International
dc.description.volume56
dc.description.issue6
dc.description.page718-728
dc.identifier.isiut000246565400004
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