Please use this identifier to cite or link to this item: https://doi.org/10.1109/TBME.2004.840463
DC FieldValue
dc.titleNonlinear control of a dynamic model of HIV-1
dc.contributor.authorGe, S.S.
dc.contributor.authorTian, Z.
dc.contributor.authorLee, T.H.
dc.date.accessioned2014-10-07T04:33:17Z
dc.date.available2014-10-07T04:33:17Z
dc.date.issued2005-03
dc.identifier.citationGe, S.S., Tian, Z., Lee, T.H. (2005-03). Nonlinear control of a dynamic model of HIV-1. IEEE Transactions on Biomedical Engineering 52 (3) : 353-361. ScholarBank@NUS Repository. https://doi.org/10.1109/TBME.2004.840463
dc.identifier.issn00189294
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/82770
dc.description.abstractHighly active antiretroviral therapy (HAART) reduces the viral burden in human immunodeficiency virus type 1 (HIV-1) infected patients. The paper addresses the problem of controlling the predator-prey like model of the interaction among CD4+ T-cell, CD8+ T-cell, and HIV-1 by an external drug agency. By exploring the dynamic properties of the system, the original system is first regrouped into two subsystems, then a nonlinear global controller is presented by designing two controllers over two complementary zones: a local controller on a finite region and a global controller over its complement. The local controller is designed to guarantee nonnegativty, and avoids the problem of control singularity within the neighborhood of the origin Ω. The complementary controller is designed via backstepping for both subsystems over the complementary region. The closed-loop system is globally stable at nominal values through the introduction of a novel bridging virtual control, and the resulting controller is singularity free and guarantees nonnegativity. In this paper, simulations are conducted in discrete-time with sampling time Ts to show the effectiveness of the proposed method. © 2005 IEEE.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1109/TBME.2004.840463
dc.sourceScopus
dc.subjectBackstepping
dc.subjectHIV-1 infection
dc.subjectNonlinear control
dc.subjectPeriodical sampling
dc.typeArticle
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.description.doi10.1109/TBME.2004.840463
dc.description.sourcetitleIEEE Transactions on Biomedical Engineering
dc.description.volume52
dc.description.issue3
dc.description.page353-361
dc.description.codenIEBEA
dc.identifier.isiut000227139500002
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