Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bios.2008.09.002
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dc.titleModification of carbon nanotubes with redox hydrogel: Improvement of amperometric sensing sensitivity for redox enzymes
dc.contributor.authorCui, H.-F.
dc.contributor.authorYe, J.-S.
dc.contributor.authorZhang, W.-D.
dc.contributor.authorSheu, F.-S.
dc.date.accessioned2014-10-07T04:32:40Z
dc.date.available2014-10-07T04:32:40Z
dc.date.issued2009-02-15
dc.identifier.citationCui, H.-F., Ye, J.-S., Zhang, W.-D., Sheu, F.-S. (2009-02-15). Modification of carbon nanotubes with redox hydrogel: Improvement of amperometric sensing sensitivity for redox enzymes. Biosensors and Bioelectronics 24 (6) : 1723-1729. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bios.2008.09.002
dc.identifier.issn09565663
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/82716
dc.description.abstractThis study demonstrated that redox hydrogel-modified carbon nanotube (CNT) electrodes can be developed as an amperometric sensor that are sensitive, specific and fast and do not require auxiliary enzymes. A redox polymer, poly(vinylimidazole) complexed with Os(4,4′-dimethylbpy)2Cl (PVI-dmeOs) was electrodeposited on Ta-supported multi-walled CNTs. The resulted PVI-dmeOs thin film did not change the surface morphology of the CNTs, but turned the CNT surface from hydrophobic to hydrophilic, as studied by scanning electron microscopy (SEM) and static water contact angle measurements. Cyclic voltammetry measurements in a Fe(CN)6 3- solution and electrochemical impedance measurements in an equimolar Fe(CN)6 3-/4- solution demonstrated that the PVI-dmeOs hydrogel thin film was electronic conductive with a resistance of about 15 Ω. The PVI-dmeOs/CNT electrodes sensed rapidly, sensitively and specifically to model redox enzymes (glucose oxidase (GOD) and lactate oxidase (LOD)) in amperometric experiments in electrolyte solutions containing the substrates of the measured redox enzymes. Both the CNT substrate and the thin PVI-dmeOs film enhanced the sensing sensitivities. Exploration of the mechanisms suggests that the PVI-dmeOs film may enhance the sensing sensitivities by wiring the enzyme molecules through the redox centers tethered on the mobile redox polymer backbones to the CNT electrodes. Crown Copyright © 2008.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bios.2008.09.002
dc.sourceScopus
dc.subjectAmperometry
dc.subjectCarbon nanotubes
dc.subjectElectrochemical sensor
dc.subjectEnzyme activity
dc.subjectRedox enzymes
dc.subjectRedox polymer
dc.typeArticle
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.description.doi10.1016/j.bios.2008.09.002
dc.description.sourcetitleBiosensors and Bioelectronics
dc.description.volume24
dc.description.issue6
dc.description.page1723-1729
dc.description.codenBBIOE
dc.identifier.isiut000263778000031
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