Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.12-10415
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dc.titleIn vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure
dc.contributor.authorZheng, C.
dc.contributor.authorCheung, C.Y.
dc.contributor.authorAung, T.
dc.contributor.authorNarayanaswamy, A.
dc.contributor.authorOng, S.-H.
dc.contributor.authorFriedman, D.S.
dc.contributor.authorAllen, J.C.
dc.contributor.authorBaskaran, M.
dc.contributor.authorChew, P.T.
dc.contributor.authorPerera, S.A.
dc.date.accessioned2014-10-07T04:30:23Z
dc.date.available2014-10-07T04:30:23Z
dc.date.issued2012-10
dc.identifier.citationZheng, C., Cheung, C.Y., Aung, T., Narayanaswamy, A., Ong, S.-H., Friedman, D.S., Allen, J.C., Baskaran, M., Chew, P.T., Perera, S.A. (2012-10). In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure. Investigative Ophthalmology and Visual Science 53 (11) : 6756-6762. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-10415
dc.identifier.issn01460404
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/82524
dc.description.abstractPURPOSE: To evaluate the acceleration of pupil constriction (APC) in response to illumination using video anterior segment optical coherence tomography (AS-OCT) in angle closure and normal eyes. METHODS: This was an observational study of 342 Chinese subjects. Iris and angle changes in response to illumination were captured with real-time video recordings of AS-OCT and analyzed frame by frame. APC was calculated using a quadratic function, fitting pupil diameter to a time series. APC was divided into two vector components: acceleration of pupil block (APB) acting perpendicular to the lens surface and acceleration of iris stretch (AIS) acting toward the iris root. RESULTS: Of 342 eligible patients, 306 (89.5%) were available for analysis; of whom 136 (41.7%) had angle closure. After adjusting for age, sex, baseline pupil diameter, and iris thickness, APC was significantly lower in angle closure eyes (0.61 mm/s2) than in open-angle eyes (0.90 mm/s2) (P < 0.0001) as was AIS (0.58 mm/ s2 vs. 0.89 mm/s2) (P < 0.001). APB was significantly higher in angle closure eyes compared to open-angle eyes (0.14 mm/s2 vs. 0.09 mm/s2) (P < 0.001). After adjusting for age and sex in logistic regression, the magnitude and direction of all vector parameters were significantly associated with presence of angle closure. CONCLUSIONS: Angle closure eyes have smaller AIS and larger APB in response to illumination as measured using AS-OCT videography. This shows that, comparatively, the iris of angle closure eyes stretches less and develops a more convex configuration in response to illumination. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.12-10415
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.description.doi10.1167/iovs.12-10415
dc.description.sourcetitleInvestigative Ophthalmology and Visual Science
dc.description.volume53
dc.description.issue11
dc.description.page6756-6762
dc.description.codenIOVSD
dc.identifier.isiut000310589900003
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