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|dc.title||In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure|
|dc.identifier.citation||Zheng, C., Cheung, C.Y., Aung, T., Narayanaswamy, A., Ong, S.-H., Friedman, D.S., Allen, J.C., Baskaran, M., Chew, P.T., Perera, S.A. (2012-10). In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure. Investigative Ophthalmology and Visual Science 53 (11) : 6756-6762. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-10415|
|dc.description.abstract||PURPOSE: To evaluate the acceleration of pupil constriction (APC) in response to illumination using video anterior segment optical coherence tomography (AS-OCT) in angle closure and normal eyes. METHODS: This was an observational study of 342 Chinese subjects. Iris and angle changes in response to illumination were captured with real-time video recordings of AS-OCT and analyzed frame by frame. APC was calculated using a quadratic function, fitting pupil diameter to a time series. APC was divided into two vector components: acceleration of pupil block (APB) acting perpendicular to the lens surface and acceleration of iris stretch (AIS) acting toward the iris root. RESULTS: Of 342 eligible patients, 306 (89.5%) were available for analysis; of whom 136 (41.7%) had angle closure. After adjusting for age, sex, baseline pupil diameter, and iris thickness, APC was significantly lower in angle closure eyes (0.61 mm/s2) than in open-angle eyes (0.90 mm/s2) (P < 0.0001) as was AIS (0.58 mm/ s2 vs. 0.89 mm/s2) (P < 0.001). APB was significantly higher in angle closure eyes compared to open-angle eyes (0.14 mm/s2 vs. 0.09 mm/s2) (P < 0.001). After adjusting for age and sex in logistic regression, the magnitude and direction of all vector parameters were significantly associated with presence of angle closure. CONCLUSIONS: Angle closure eyes have smaller AIS and larger APB in response to illumination as measured using AS-OCT videography. This shows that, comparatively, the iris of angle closure eyes stretches less and develops a more convex configuration in response to illumination. © 2012 The Association for Research in Vision and Ophthalmology, Inc.|
|dc.contributor.department||ELECTRICAL & COMPUTER ENGINEERING|
|dc.description.sourcetitle||Investigative Ophthalmology and Visual Science|
|Appears in Collections:||Staff Publications|
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