Please use this identifier to cite or link to this item:
|Title:||In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure||Authors:||Zheng, C.
|Issue Date:||Oct-2012||Citation:||Zheng, C., Cheung, C.Y., Aung, T., Narayanaswamy, A., Ong, S.-H., Friedman, D.S., Allen, J.C., Baskaran, M., Chew, P.T., Perera, S.A. (2012-10). In vivo analysis of vectors involved in pupil constriction in Chinese subjects with angle closure. Investigative Ophthalmology and Visual Science 53 (11) : 6756-6762. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-10415||Abstract:||PURPOSE: To evaluate the acceleration of pupil constriction (APC) in response to illumination using video anterior segment optical coherence tomography (AS-OCT) in angle closure and normal eyes. METHODS: This was an observational study of 342 Chinese subjects. Iris and angle changes in response to illumination were captured with real-time video recordings of AS-OCT and analyzed frame by frame. APC was calculated using a quadratic function, fitting pupil diameter to a time series. APC was divided into two vector components: acceleration of pupil block (APB) acting perpendicular to the lens surface and acceleration of iris stretch (AIS) acting toward the iris root. RESULTS: Of 342 eligible patients, 306 (89.5%) were available for analysis; of whom 136 (41.7%) had angle closure. After adjusting for age, sex, baseline pupil diameter, and iris thickness, APC was significantly lower in angle closure eyes (0.61 mm/s2) than in open-angle eyes (0.90 mm/s2) (P < 0.0001) as was AIS (0.58 mm/ s2 vs. 0.89 mm/s2) (P < 0.001). APB was significantly higher in angle closure eyes compared to open-angle eyes (0.14 mm/s2 vs. 0.09 mm/s2) (P < 0.001). After adjusting for age and sex in logistic regression, the magnitude and direction of all vector parameters were significantly associated with presence of angle closure. CONCLUSIONS: Angle closure eyes have smaller AIS and larger APB in response to illumination as measured using AS-OCT videography. This shows that, comparatively, the iris of angle closure eyes stretches less and develops a more convex configuration in response to illumination. © 2012 The Association for Research in Vision and Ophthalmology, Inc.||Source Title:||Investigative Ophthalmology and Visual Science||URI:||http://scholarbank.nus.edu.sg/handle/10635/82524||ISSN:||01460404||DOI:||10.1167/iovs.12-10415|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 26, 2021
WEB OF SCIENCETM
checked on Feb 26, 2021
checked on Mar 1, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.