Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2010.09.016
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dc.titleEngineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma
dc.contributor.authorJeun, M.
dc.contributor.authorJeoung, J.W.
dc.contributor.authorMoon, S.
dc.contributor.authorKim, Y.J.
dc.contributor.authorLee, S.
dc.contributor.authorPaek, S.H.
dc.contributor.authorChung, K.-W.
dc.contributor.authorPark, K.H.
dc.contributor.authorBae, S.
dc.date.accessioned2014-10-07T04:27:32Z
dc.date.available2014-10-07T04:27:32Z
dc.date.issued2011-01
dc.identifier.citationJeun, M., Jeoung, J.W., Moon, S., Kim, Y.J., Lee, S., Paek, S.H., Chung, K.-W., Park, K.H., Bae, S. (2011-01). Engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma. Biomaterials 32 (2) : 387-394. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2010.09.016
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/82282
dc.description.abstractOcular neuroprotection induced by localized heat shock proteins (HSPs) has been paid considerable attention as an efficacious treatment modality for glaucoma. However, the current clinical approaches to induce HSPs in the retinal ganglion cells (RGCs) are limited due to undesirable side effects. Here, we present that the induction of HSPs by local magnetic hyperthermia using engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticle agents (EMZF-SPNPAs) with a 5.5 nm mean particle size is promisingly feasible for a physiologically tolerable ocular neuroprotection modality. The sufficiently high specific absorption rate (SAR) (~256.4 W/g in an agar solution) achieved at the biologically safe range of applied AC magnetic field and frequency as well as the superior biocompatibility of EMZF-SPNPA, which were confirmed from both in-vitro and in-vivo animal pilot studies, allowing it to be considered as a potential localized HSPs agent. Furthermore, the successful demonstration of a newly designed infusion technique, which diffuses the EMZF-SPNPAs through the vitreous body to the retina in a rat eye, more strongly verified the promises of this biotechnical approach to the ocular neuroprotection modality in glaucoma clinics. © 2010 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2010.09.016
dc.sourceScopus
dc.subjectAC magnetically-induced heating
dc.subjectGlaucoma
dc.subjectHeat shock protein
dc.subjectHyperthermia
dc.subjectOcular neuroprotection
dc.subjectSuperparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles
dc.typeArticle
dc.contributor.departmentELECTRICAL & COMPUTER ENGINEERING
dc.description.doi10.1016/j.biomaterials.2010.09.016
dc.description.sourcetitleBiomaterials
dc.description.volume32
dc.description.issue2
dc.description.page387-394
dc.description.codenBIMAD
dc.identifier.isiut000285401500007
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