Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2010.09.016
Title: Engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma
Authors: Jeun, M.
Jeoung, J.W.
Moon, S. 
Kim, Y.J.
Lee, S. 
Paek, S.H.
Chung, K.-W.
Park, K.H.
Bae, S. 
Keywords: AC magnetically-induced heating
Glaucoma
Heat shock protein
Hyperthermia
Ocular neuroprotection
Superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles
Issue Date: Jan-2011
Citation: Jeun, M., Jeoung, J.W., Moon, S., Kim, Y.J., Lee, S., Paek, S.H., Chung, K.-W., Park, K.H., Bae, S. (2011-01). Engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticles as a heat shock protein induction agent for ocular neuroprotection in glaucoma. Biomaterials 32 (2) : 387-394. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2010.09.016
Abstract: Ocular neuroprotection induced by localized heat shock proteins (HSPs) has been paid considerable attention as an efficacious treatment modality for glaucoma. However, the current clinical approaches to induce HSPs in the retinal ganglion cells (RGCs) are limited due to undesirable side effects. Here, we present that the induction of HSPs by local magnetic hyperthermia using engineered superparamagnetic Mn0.5Zn0.5Fe2O4 nanoparticle agents (EMZF-SPNPAs) with a 5.5 nm mean particle size is promisingly feasible for a physiologically tolerable ocular neuroprotection modality. The sufficiently high specific absorption rate (SAR) (~256.4 W/g in an agar solution) achieved at the biologically safe range of applied AC magnetic field and frequency as well as the superior biocompatibility of EMZF-SPNPA, which were confirmed from both in-vitro and in-vivo animal pilot studies, allowing it to be considered as a potential localized HSPs agent. Furthermore, the successful demonstration of a newly designed infusion technique, which diffuses the EMZF-SPNPAs through the vitreous body to the retina in a rat eye, more strongly verified the promises of this biotechnical approach to the ocular neuroprotection modality in glaucoma clinics. © 2010 Elsevier Ltd.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/82282
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2010.09.016
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on Dec 10, 2019

WEB OF SCIENCETM
Citations

22
checked on Dec 3, 2019

Page view(s)

47
checked on Nov 30, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.