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Title: A mathematical model for ATP-mediated calcium dynamics in vascular endothelial cells induced by fluid shear stress
Authors: Hu, X.-Q.
Xiang, C. 
Cao, L.-L.
Xu, Z.
Qin, K.-R. 
Keywords: ATP (adenosine triphosphate)
Dynamic model
Shear stress
Static model
Vascular endothelial cells
Issue Date: Oct-2008
Citation: Hu, X.-Q., Xiang, C., Cao, L.-L., Xu, Z., Qin, K.-R. (2008-10). A mathematical model for ATP-mediated calcium dynamics in vascular endothelial cells induced by fluid shear stress. Applied Mathematics and Mechanics (English Edition) 29 (10) : 1291-1298. ScholarBank@NUS Repository.
Abstract: In consideration of the mechanism for shear-stress-induced Ca2+ influx via ATP(adenosine triphosphate)-gated ion channel P2X4 in vascular endothelial cells, a modified model is proposed to describe the shear-stress-induced Ca2+ influx. It is affected both by the Ca 2+ gradient across the cell membrane and extracellular ATP concentration on the cell surface. Meanwhile, a new static ATP release model is constructed by using published experimental data. Combining the modified intracellular calcium dynamics model with the new ATP release model, we establish a nonlinear Ca2+ dynamic system in vascular endothelial cells. The ATP-mediated calcium response in vascular endothelial cells subjected to shear stresses is analyzed by solving the governing equations of the integrated dynamic system. Numerical results show that the shear-stress-induced calcium response predicted by the proposed model is more consistent with the experimental observations than that predicted by existing models. © 2008 Shanghai University and Springer-Verlag GmbH.
Source Title: Applied Mathematics and Mechanics (English Edition)
ISSN: 02534827
DOI: 10.1007/s10483-008-1004-4
Appears in Collections:Staff Publications

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