Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.mbs.2013.04.005
DC Field | Value | |
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dc.title | A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation | |
dc.contributor.author | Sun, G.-X. | |
dc.contributor.author | Wang, L.-J. | |
dc.contributor.author | Xiang, C. | |
dc.contributor.author | Qin, K.-R. | |
dc.date.accessioned | 2014-10-07T04:22:36Z | |
dc.date.available | 2014-10-07T04:22:36Z | |
dc.date.issued | 2013-07 | |
dc.identifier.citation | Sun, G.-X., Wang, L.-J., Xiang, C., Qin, K.-R. (2013-07). A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation. Mathematical Biosciences 244 (1) : 47-57. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mbs.2013.04.005 | |
dc.identifier.issn | 00255564 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/81864 | |
dc.description.abstract | Regulation of intracellular calcium ion concentration ([Ca2+]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+]in dynamics by controlling the external electrical stimulation. © 2013 Elsevier Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.mbs.2013.04.005 | |
dc.source | Scopus | |
dc.subject | Calcium ion channels | |
dc.subject | Dynamic model | |
dc.subject | Electrical stimulation | |
dc.subject | Fibroblasts | |
dc.subject | Intracellular calcium ion concentration | |
dc.type | Article | |
dc.contributor.department | ELECTRICAL & COMPUTER ENGINEERING | |
dc.description.doi | 10.1016/j.mbs.2013.04.005 | |
dc.description.sourcetitle | Mathematical Biosciences | |
dc.description.volume | 244 | |
dc.description.issue | 1 | |
dc.description.page | 47-57 | |
dc.description.coden | MABIA | |
dc.identifier.isiut | 000320747800006 | |
Appears in Collections: | Staff Publications |
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