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Title: A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation
Authors: Sun, G.-X.
Wang, L.-J.
Xiang, C. 
Qin, K.-R.
Keywords: Calcium ion channels
Dynamic model
Electrical stimulation
Intracellular calcium ion concentration
Issue Date: Jul-2013
Citation: Sun, G.-X., Wang, L.-J., Xiang, C., Qin, K.-R. (2013-07). A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation. Mathematical Biosciences 244 (1) : 47-57. ScholarBank@NUS Repository.
Abstract: Regulation of intracellular calcium ion concentration ([Ca2+]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+]in dynamics by controlling the external electrical stimulation. © 2013 Elsevier Inc.
Source Title: Mathematical Biosciences
ISSN: 00255564
DOI: 10.1016/j.mbs.2013.04.005
Appears in Collections:Staff Publications

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