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https://doi.org/10.1016/j.mbs.2013.04.005
Title: | A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation | Authors: | Sun, G.-X. Wang, L.-J. Xiang, C. Qin, K.-R. |
Keywords: | Calcium ion channels Dynamic model Electrical stimulation Fibroblasts Intracellular calcium ion concentration |
Issue Date: | Jul-2013 | Citation: | Sun, G.-X., Wang, L.-J., Xiang, C., Qin, K.-R. (2013-07). A dynamic model for intracellular calcium response in fibroblasts induced by electrical stimulation. Mathematical Biosciences 244 (1) : 47-57. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mbs.2013.04.005 | Abstract: | Regulation of intracellular calcium ion concentration ([Ca2+]in) in fibroblasts induced by exogenous electrical stimulation could be applied to control gene expressions selectively which in turn modulate the function of the fibroblasts. Regarding the mechanism for electric-field-induced Ca2+ influx via voltage-gated Ca2+ channels and/or stretch-activated cation channels in the fibroblasts, a dynamic mathematical model is proposed to quantify the [Ca2+]in dynamics in response to direct current or alternating current electric fields. Simulation results demonstrate that the changes in [Ca2+]in predicted by our dynamic model are consistent with the experimental data in the literature. The proposed dynamic model could provide not only more insights into the electric-field-induced intracellular Ca2+ response but also a quantitative way to regulate the [Ca2+]in dynamics by controlling the external electrical stimulation. © 2013 Elsevier Inc. | Source Title: | Mathematical Biosciences | URI: | http://scholarbank.nus.edu.sg/handle/10635/81864 | ISSN: | 00255564 | DOI: | 10.1016/j.mbs.2013.04.005 |
Appears in Collections: | Staff Publications |
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