Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/80225
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dc.titleDEVELOPMENT AND CHARACTERIZATION OF DNA APTAMERS THAT TARGET GLUTEN PEPTIDES RESPONSIBLE FOR CELIAC DISEASE DEVELOPMENT
dc.contributor.authorROOPSHA BRAHMA
dc.date.accessioned2014-09-30T18:01:34Z
dc.date.available2014-09-30T18:01:34Z
dc.date.issued2013-08-22
dc.identifier.citationROOPSHA BRAHMA (2013-08-22). DEVELOPMENT AND CHARACTERIZATION OF DNA APTAMERS THAT TARGET GLUTEN PEPTIDES RESPONSIBLE FOR CELIAC DISEASE DEVELOPMENT. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/80225
dc.description.abstractCELIAC DISEASE IS TRIGGERED BY EXPOSURE TO WHEAT GLUTEN AND SIMILAR PROTEINS FOUND IN BARLEY AND RYE. WE SELECTED TWO SETS OF SINGLE STRAND DNA APTAMERS THAT TARGET THE IMMUNODOMINANT 33-MER GLUTEN EPITOPE AND INVESTIGATED THEIR ABILITY TO PREVENT GLUTEN-INDUCED AUTOIMMUNITY. THE FIRST SET OF APTAMERS, WHICH BIND TO THE NATIVE 33-MER GLUTEN PEPTIDE (LQLQPFPQPQLPYPQPQPLYPQPQLPYPQPQPF), INHIBITS TISSUE TRANSGLUTAMINASE-MEDIATED DEAMIDATION WHICH IS A NECESSARY STEP IN CELIAC DISEASE DEVELOPMENT. THE SECOND SET OF APTAMERS, WHICH BIND TO THE DEAMIDATED 33-MER GLUTEN PEPTIDE (LQLQPFPQPELPYPQPEPLYPQPELPYPQPQPF), HINDERS EPITOPE LOADING ONTO HLA-DQ2. THESE APTAMERS MAY SERVE AS A PREVENTIVE THERAPEUTIC FOR CELIAC DISEASE.
dc.language.isoen
dc.subjectAptamer, Celiac disease, autoimmune disorder, tissue transglutaminase, DQ2
dc.typeThesis
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.supervisorKIM CHU-YOUNG
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

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