Please use this identifier to cite or link to this item: https://doi.org/10.1021/nl4032549
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dc.titleNanoparticles strengthen intracellular tension and retard cellular migration
dc.contributor.authorTay, C.Y.
dc.contributor.authorCai, P.
dc.contributor.authorSetyawati, M.I.
dc.contributor.authorFang, W.
dc.contributor.authorTan, L.P.
dc.contributor.authorHong, C.H.L.
dc.contributor.authorChen, X.
dc.contributor.authorLeong, D.T.
dc.date.accessioned2014-09-18T10:00:51Z
dc.date.available2014-09-18T10:00:51Z
dc.date.issued2014-01-08
dc.identifier.citationTay, C.Y., Cai, P., Setyawati, M.I., Fang, W., Tan, L.P., Hong, C.H.L., Chen, X., Leong, D.T. (2014-01-08). Nanoparticles strengthen intracellular tension and retard cellular migration. Nano Letters 14 (1) : 83-88. ScholarBank@NUS Repository. https://doi.org/10.1021/nl4032549
dc.identifier.issn15306984
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/79971
dc.description.abstractNanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility. © 2013 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/nl4032549
dc.sourceScopus
dc.subjectcell migration
dc.subjectcell traction force
dc.subjectmicrotubules
dc.subjectnanobio interactions
dc.subjectNanoparticles
dc.typeArticle
dc.contributor.departmentDENTISTRY
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1021/nl4032549
dc.description.sourcetitleNano Letters
dc.description.volume14
dc.description.issue1
dc.description.page83-88
dc.description.codenNALEF
dc.identifier.isiut000329586700014
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