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Title: Nanoparticles strengthen intracellular tension and retard cellular migration
Authors: Tay, C.Y.
Cai, P.
Setyawati, M.I.
Fang, W. 
Tan, L.P.
Hong, C.H.L. 
Chen, X.
Leong, D.T. 
Keywords: cell migration
cell traction force
nanobio interactions
Issue Date: 8-Jan-2014
Citation: Tay, C.Y., Cai, P., Setyawati, M.I., Fang, W., Tan, L.P., Hong, C.H.L., Chen, X., Leong, D.T. (2014-01-08). Nanoparticles strengthen intracellular tension and retard cellular migration. Nano Letters 14 (1) : 83-88. ScholarBank@NUS Repository.
Abstract: Nanoparticles can have profound effects on cell biology. Here, we show that after TiO2, SiO2, and hydroxyapatite nanoparticles treatment, TR146 epithelial cell sheet displayed slower migration. Cells after exposure to the nanoparticles showed increased cell contractility with significantly impaired wound healing capability however without any apparent cytotoxicity. We showed the mechanism is through nanoparticle-mediated massive disruption of the intracellular microtubule assembly, thereby triggering a positive feedback that promoted stronger substrate adhesions thus leading to limited cell motility. © 2013 American Chemical Society.
Source Title: Nano Letters
ISSN: 15306984
DOI: 10.1021/nl4032549
Appears in Collections:Staff Publications

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