Please use this identifier to cite or link to this item: https://doi.org/10.1111/iej.12150
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dc.titleHuman embryonic stem cell differentiation into odontoblastic lineage: An in vitro study
dc.contributor.authorKidwai, F.K.
dc.contributor.authorMovahednia, M.M.
dc.contributor.authorIqbal, K.
dc.contributor.authorJokhun, D.S.
dc.contributor.authorCao, T.
dc.contributor.authorFawzy, A.S.
dc.date.accessioned2014-09-18T09:22:37Z
dc.date.available2014-09-18T09:22:37Z
dc.date.issued2014-04
dc.identifier.citationKidwai, F.K., Movahednia, M.M., Iqbal, K., Jokhun, D.S., Cao, T., Fawzy, A.S. (2014-04). Human embryonic stem cell differentiation into odontoblastic lineage: An in vitro study. International Endodontic Journal 47 (4) : 346-355. ScholarBank@NUS Repository. https://doi.org/10.1111/iej.12150
dc.identifier.issn01432885
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/79908
dc.description.abstractAim: The aim of this study was to differentiate human embryonic stem cells (hESCs) into odontoblastic lineage in an optimized culture milieu. Methodology: In Phase 1, hESCs were differentiated into mesenchymal stem cells (H9-MSCs). In Phase 2, H9-MSCs were then differentiated into odontoblast-like cells (H9-Odont) under the stimulation of FGF-8 and BMP-4. Alternatively, H9-MSCs were differentiated into osteogenic lineage (H9-Osteo). In Phase 3, H9-Odont were seeded on 17% EDTA-treated dentine substrates in the presence of FGF-8 and BMP-4 for further differentiation. All experiments were performed in triplicate (n = 3). One-way anova was used to test hESC differentiation into different cell types. Post hoc Tukey's test was used to compare between groups. P 
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/iej.12150
dc.sourceScopus
dc.subjectDentine
dc.subjectGrowth factors
dc.subjectHuman embryonic stem cells
dc.subjectMesenchymal stem cells
dc.subjectOdontoblastic differentiation
dc.typeArticle
dc.contributor.departmentDENTISTRY
dc.description.doi10.1111/iej.12150
dc.description.sourcetitleInternational Endodontic Journal
dc.description.volume47
dc.description.issue4
dc.description.page346-355
dc.description.codenIENJE
dc.identifier.isiut000332425800006
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