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|dc.title||Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin|
|dc.identifier.citation||Vinoth, J.K., Patel, K.J., Lih, W.-S., Seow, Y.-S., Cao, T., Meikle, M.C. (2013-12). Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin. European Journal of Oral Sciences 121 (6) : 517-524. ScholarBank@NUS Repository. https://doi.org/10.1111/eos.12091|
|dc.description.abstract||To understand, in greater detail, the molecular mechanisms regulating the complex relationship between mechanical strain and alveolar bone metabolism during orthodontic treatment, passive cross-arch palatal springs were bonded to the maxillary molars of 6-wk-old rats, which were killed after 4 and 8 d. Outcome measures included serum assays for markers of bone formation and resorption and for the multifunctional hormone leptin, and histomorphometry of the inter-radicular bone. The concentration of the bone-formation marker alkaline phosphatase (ALP) was significantly reduced at both time points in the appliance group, accompanied by a 50% reduction in inter-radicular bone volume; however, osteocalcin (bone Gla protein) levels remained unaffected. Bone collagen deoxypyridinoline (DPD) crosslinks increased 2.3-fold at 4 d only, indicating a transient increase in bone resorption; in contrast, the level of the osteoclast-specific marker, tartrate-resistant acid phosphatase 5b (TRACP 5b), was unchanged. Leptin levels closely paralleled ALP reductions at both time points, suggesting an important role in the mechanostat negative-feedback loop required to normalize bone mass. These data suggest that an orthodontic appliance, in addition to remodeling the periodontal ligament (PDL)-bone interface, may exert unexpected side-effects on the tooth-supporting alveolar bone, and highlights the importance of recognizing that bone strains can have negative, as well as positive, effects on bone mass. © 2013 Eur J Oral Sci.|
|dc.subject||Tartrate-resistant acid phosphatase 5b|
|dc.description.sourcetitle||European Journal of Oral Sciences|
|Appears in Collections:||Staff Publications|
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