Please use this identifier to cite or link to this item:
Title: Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin
Authors: Vinoth, J.K. 
Patel, K.J.
Lih, W.-S.
Seow, Y.-S.
Cao, T. 
Meikle, M.C. 
Keywords: Alkaline phosphatase
Deoxypyridinoline crosslinks
Tartrate-resistant acid phosphatase 5b
Issue Date: Dec-2013
Citation: Vinoth, J.K., Patel, K.J., Lih, W.-S., Seow, Y.-S., Cao, T., Meikle, M.C. (2013-12). Appliance-induced osteopenia of dentoalveolar bone in the rat: Effect of reduced bone strains on serum bone markers and the multifunctional hormone leptin. European Journal of Oral Sciences 121 (6) : 517-524. ScholarBank@NUS Repository.
Abstract: To understand, in greater detail, the molecular mechanisms regulating the complex relationship between mechanical strain and alveolar bone metabolism during orthodontic treatment, passive cross-arch palatal springs were bonded to the maxillary molars of 6-wk-old rats, which were killed after 4 and 8 d. Outcome measures included serum assays for markers of bone formation and resorption and for the multifunctional hormone leptin, and histomorphometry of the inter-radicular bone. The concentration of the bone-formation marker alkaline phosphatase (ALP) was significantly reduced at both time points in the appliance group, accompanied by a 50% reduction in inter-radicular bone volume; however, osteocalcin (bone Gla protein) levels remained unaffected. Bone collagen deoxypyridinoline (DPD) crosslinks increased 2.3-fold at 4 d only, indicating a transient increase in bone resorption; in contrast, the level of the osteoclast-specific marker, tartrate-resistant acid phosphatase 5b (TRACP 5b), was unchanged. Leptin levels closely paralleled ALP reductions at both time points, suggesting an important role in the mechanostat negative-feedback loop required to normalize bone mass. These data suggest that an orthodontic appliance, in addition to remodeling the periodontal ligament (PDL)-bone interface, may exert unexpected side-effects on the tooth-supporting alveolar bone, and highlights the importance of recognizing that bone strains can have negative, as well as positive, effects on bone mass. © 2013 Eur J Oral Sci.
Source Title: European Journal of Oral Sciences
ISSN: 09098836
DOI: 10.1111/eos.12091
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jan 17, 2022


checked on Oct 1, 2021

Page view(s)

checked on Jan 20, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.