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|Title:||DESIGN AND IMPLEMENTATION OF A NOVEL LAPLACE-DOMAIN DIFFUSE OPTICAL TOMOGRAPHY AND ITS APPLICATION FOR BRAIN IMAGING||Authors:||ALI HASNAIN||Keywords:||Diffuse Optical Tomography, Time-resolved, Laplace transformation, Pseudorandom bit sequence (PRBS), Hemodynamic changes, Functional imaging||Issue Date:||24-Jan-2014||Citation:||ALI HASNAIN (2014-01-24). DESIGN AND IMPLEMENTATION OF A NOVEL LAPLACE-DOMAIN DIFFUSE OPTICAL TOMOGRAPHY AND ITS APPLICATION FOR BRAIN IMAGING. ScholarBank@NUS Repository.||Abstract:||This doctoral research work aims at designing and implementation of a spread-spectrum correlation-based novel Laplace-domain DOT system and explore its potential for human brain imaging. The system architecture is based on laser intensity modulation with a high-speed pseudo-random bit sequence (PRBS) and cross-correlating the optical signal from the biological tissue with the identical PRBS, to retrieve the time-dependent measurements of diffusive photons propagating through the tissue. A direct Laplace transformation of the time-resolved signal is implemented to extract feature dataset which significantly reduces data acquisition time or increase signal-to-noise ratio. The imaging system with 40 channels is evaluated using static and dynamic optical phantoms and hemodynamic changes are measured in the prefrontal cortex by designing a few mental activity tasks. The results of preliminary in vivo experiments are in agreement with literature. In addition, the system has a small form factor which makes it portable.||URI:||http://scholarbank.nus.edu.sg/handle/10635/79480|
|Appears in Collections:||Ph.D Theses (Open)|
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