CYCLODEXTRIN-BASED POLYMERIC SUPRAMOLECULAR SELF-ASSEMBLY SYSTEM FOR ANTICANCER THERAPEUTICS DELIVERY

Abstract

The objective of this research was to develop a supramolecular block building approach based on “Molecular LEGO®” strategy to construct and optimize efficient gene and drug delivery systems for cancer therapy. This supramolecular approach was based on the host-guest interaction between beta-cyclodxtrin and adamantyl moieties in the host and guest. Compared to traditional covalent conjugation block building approaches, this supramolecular approach, like the assembly of “LEGO® bricks”, is more convenient in building complicated architectures with multiple functionalities integrated within one system. Firstly, we applied this supramolecular approach for building a smart carrier system with the functions of reduction-responsiveness and biomimetic switchable shielding for DNA delivery. Secondly, with the aim of precise construction of multifunctional siRNA targeted delivery vehicle for cancer gene therapy, we applied this supramolecular block building “LEGO® bricks” concept to develop a “pegs into hole” screening platform to screen various architectures of siRNA targeting delivery system. Thirdly, with the objective of combining chemotherapy and gene therapy technology for the treatment of multidrug resistant cancer, we applied the supramolecular building block strategy in developing a dual-stimuli responsive vesicular carrier to accommodate combination of anticancer drug doxorubicin (DOX) and siRNA for reversal of drug sensitivity. Firstly, we applied this supramolecular approach for building a smart carrier system with the functions of reduction-responsiveness and biomimetic switchable shielding for DNA delivery. Secondly, with the aim of precise construction of multifunctional siRNA targeted delivery vehicle for cancer gene therapy, we applied this supramolecular block building “LEGO® bricks” concept to develop a “pegs into hole” screening platform to screen various architectures of siRNA targeting delivery system. Thirdly, with the objective of combining chemotherapy and gene therapy technology for the treatment of multidrug resistant cancer, we applied the supramolecular building block strategy in developing a dual-stimuli responsive vesicular carrier to accommodate combination of anticancer drug doxorubicin (DOX) and siRNA for reversal of drug sensitivity.