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Title: Simulating calcineurin-centered calcium signaling network in cardiac myocytes
Authors: Cui, J.
Kaandorp, J.A.
Sloot, P.M.A.
Thiagarajan, P.S. 
Keywords: Calcineurin
Calcium homeostasis
Calcium signaling
Cardiac hypertrophy
Cardiac myocytes
Issue Date: 2010
Citation: Cui, J.,Kaandorp, J.A.,Sloot, P.M.A.,Thiagarajan, P.S. (2010). Simulating calcineurin-centered calcium signaling network in cardiac myocytes. Congestive Heart Failure: Symptoms, Causes and Treatment : 111-128. ScholarBank@NUS Repository.
Abstract: Calcium ion has been found to play critical roles regulating both the beating and the growth of the heart. Mathematical modeling and computational simulations are required for understanding the complex dynamics arising from the calcium signaling networks controlling the heart growth, which is critical for devising therapeutic drugs for the treatment of pathologic hypertrophy and heart failure. In this paper, we will report our newest results of simulating the relevant calcineurin-centered calcium signaling pathways under the hypertrophic stimulus of pressure overload. We will show how the dual roles of RCAN protein in cardiac hypertrophy under different hypertrophic stimuli can be explained by the complex interactions of multiple signaling pathways and indicate how this particular example can help us understand the mystery of specificity encoding in calcium signaling networks. We will also discuss how to push forward the realistic modeling of calcium signaling network in mammalian hearts and how it can benefit from the corresponding calcium signaling research in simpler organisms such as yeast. © 2010 Nova Science Publishers, Inc. All rights reserved.
Source Title: Congestive Heart Failure: Symptoms, Causes and Treatment
ISBN: 9781608766772
Appears in Collections:Staff Publications

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