Please use this identifier to cite or link to this item: https://doi.org/10.1101/gr.154492.113
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dc.titleWhole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
dc.contributor.authorKan, Z.
dc.contributor.authorZheng, H.
dc.contributor.authorLiu, X.
dc.contributor.authorLi, S.
dc.contributor.authorBarber, T.D.
dc.contributor.authorGong, Z.
dc.contributor.authorGao, H.
dc.contributor.authorHao, K.
dc.contributor.authorWillard, M.D.
dc.contributor.authorXu, J.
dc.contributor.authorHauptschein, R.
dc.contributor.authorRejto, P.A.
dc.contributor.authorFernandez, J.
dc.contributor.authorWang, G.
dc.contributor.authorZhang, Q.
dc.contributor.authorWang, B.
dc.contributor.authorChen, R.
dc.contributor.authorWang, J.
dc.contributor.authorLee, N.P.
dc.contributor.authorZhou, W.
dc.contributor.authorLin, Z.
dc.contributor.authorPeng, Z.
dc.contributor.authorYi, K.
dc.contributor.authorChen, S.
dc.contributor.authorLi, L.
dc.contributor.authorFan, X.
dc.contributor.authorYang, J.
dc.contributor.authorYe, R.
dc.contributor.authorJu, J.
dc.contributor.authorWang, K.
dc.contributor.authorEstrella, H.
dc.contributor.authorDeng, S.
dc.contributor.authorWei, P.
dc.contributor.authorQiu, M.
dc.contributor.authorWulur, I.H.
dc.contributor.authorLiu, J.
dc.contributor.authorEhsani, M.E.
dc.contributor.authorZhang, C.
dc.contributor.authorLoboda, A.
dc.contributor.authorSung, W.K.
dc.contributor.authorAggarwal, A.
dc.contributor.authorPoon, R.T.
dc.contributor.authorFan, S.T.
dc.contributor.authorWang, J.
dc.contributor.authorHardwick, J.
dc.contributor.authorReinhard, C.
dc.contributor.authorDai, H.
dc.contributor.authorLi, Y.
dc.contributor.authorLuk, J.M.
dc.contributor.authorMao, M.
dc.date.accessioned2014-07-04T03:10:40Z
dc.date.available2014-07-04T03:10:40Z
dc.date.issued2013-09
dc.identifier.citationKan, Z., Zheng, H., Liu, X., Li, S., Barber, T.D., Gong, Z., Gao, H., Hao, K., Willard, M.D., Xu, J., Hauptschein, R., Rejto, P.A., Fernandez, J., Wang, G., Zhang, Q., Wang, B., Chen, R., Wang, J., Lee, N.P., Zhou, W., Lin, Z., Peng, Z., Yi, K., Chen, S., Li, L., Fan, X., Yang, J., Ye, R., Ju, J., Wang, K., Estrella, H., Deng, S., Wei, P., Qiu, M., Wulur, I.H., Liu, J., Ehsani, M.E., Zhang, C., Loboda, A., Sung, W.K., Aggarwal, A., Poon, R.T., Fan, S.T., Wang, J., Hardwick, J., Reinhard, C., Dai, H., Li, Y., Luk, J.M., Mao, M. (2013-09). Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Research 23 (9) : 1422-1433. ScholarBank@NUS Repository. https://doi.org/10.1101/gr.154492.113
dc.identifier.issn10889051
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77946
dc.description.abstractHepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV-associated HCC. We find beta-catenin to be the most frequently mutated oncogene (15.9%) and TP53 the most frequently mutated tumor suppressor (35.2%). TheWnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases, respectively, are likely to act as two major oncogenic drivers in HCC. This study also identifies several prevalent and potentially actionable mutations, including activating mutations of Janus kinase 1 ( JAK1), in 9.1% of patients and provides a path toward therapeutic intervention of the disease. © 2013, Published by Cold Spring Harbor Laboratory Press.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1101/gr.154492.113
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMPUTER SCIENCE
dc.description.doi10.1101/gr.154492.113
dc.description.sourcetitleGenome Research
dc.description.volume23
dc.description.issue9
dc.description.page1422-1433
dc.description.codenGEREF
dc.identifier.isiut000324080000006
Appears in Collections:Staff Publications

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