Please use this identifier to cite or link to this item:
https://doi.org/10.1101/gr.154492.113
DC Field | Value | |
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dc.title | Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma | |
dc.contributor.author | Kan, Z. | |
dc.contributor.author | Zheng, H. | |
dc.contributor.author | Liu, X. | |
dc.contributor.author | Li, S. | |
dc.contributor.author | Barber, T.D. | |
dc.contributor.author | Gong, Z. | |
dc.contributor.author | Gao, H. | |
dc.contributor.author | Hao, K. | |
dc.contributor.author | Willard, M.D. | |
dc.contributor.author | Xu, J. | |
dc.contributor.author | Hauptschein, R. | |
dc.contributor.author | Rejto, P.A. | |
dc.contributor.author | Fernandez, J. | |
dc.contributor.author | Wang, G. | |
dc.contributor.author | Zhang, Q. | |
dc.contributor.author | Wang, B. | |
dc.contributor.author | Chen, R. | |
dc.contributor.author | Wang, J. | |
dc.contributor.author | Lee, N.P. | |
dc.contributor.author | Zhou, W. | |
dc.contributor.author | Lin, Z. | |
dc.contributor.author | Peng, Z. | |
dc.contributor.author | Yi, K. | |
dc.contributor.author | Chen, S. | |
dc.contributor.author | Li, L. | |
dc.contributor.author | Fan, X. | |
dc.contributor.author | Yang, J. | |
dc.contributor.author | Ye, R. | |
dc.contributor.author | Ju, J. | |
dc.contributor.author | Wang, K. | |
dc.contributor.author | Estrella, H. | |
dc.contributor.author | Deng, S. | |
dc.contributor.author | Wei, P. | |
dc.contributor.author | Qiu, M. | |
dc.contributor.author | Wulur, I.H. | |
dc.contributor.author | Liu, J. | |
dc.contributor.author | Ehsani, M.E. | |
dc.contributor.author | Zhang, C. | |
dc.contributor.author | Loboda, A. | |
dc.contributor.author | Sung, W.K. | |
dc.contributor.author | Aggarwal, A. | |
dc.contributor.author | Poon, R.T. | |
dc.contributor.author | Fan, S.T. | |
dc.contributor.author | Wang, J. | |
dc.contributor.author | Hardwick, J. | |
dc.contributor.author | Reinhard, C. | |
dc.contributor.author | Dai, H. | |
dc.contributor.author | Li, Y. | |
dc.contributor.author | Luk, J.M. | |
dc.contributor.author | Mao, M. | |
dc.date.accessioned | 2014-07-04T03:10:40Z | |
dc.date.available | 2014-07-04T03:10:40Z | |
dc.date.issued | 2013-09 | |
dc.identifier.citation | Kan, Z., Zheng, H., Liu, X., Li, S., Barber, T.D., Gong, Z., Gao, H., Hao, K., Willard, M.D., Xu, J., Hauptschein, R., Rejto, P.A., Fernandez, J., Wang, G., Zhang, Q., Wang, B., Chen, R., Wang, J., Lee, N.P., Zhou, W., Lin, Z., Peng, Z., Yi, K., Chen, S., Li, L., Fan, X., Yang, J., Ye, R., Ju, J., Wang, K., Estrella, H., Deng, S., Wei, P., Qiu, M., Wulur, I.H., Liu, J., Ehsani, M.E., Zhang, C., Loboda, A., Sung, W.K., Aggarwal, A., Poon, R.T., Fan, S.T., Wang, J., Hardwick, J., Reinhard, C., Dai, H., Li, Y., Luk, J.M., Mao, M. (2013-09). Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Research 23 (9) : 1422-1433. ScholarBank@NUS Repository. https://doi.org/10.1101/gr.154492.113 | |
dc.identifier.issn | 10889051 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/77946 | |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes and pathways implicated in HBV-associated HCC. We find beta-catenin to be the most frequently mutated oncogene (15.9%) and TP53 the most frequently mutated tumor suppressor (35.2%). TheWnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases, respectively, are likely to act as two major oncogenic drivers in HCC. This study also identifies several prevalent and potentially actionable mutations, including activating mutations of Janus kinase 1 ( JAK1), in 9.1% of patients and provides a path toward therapeutic intervention of the disease. © 2013, Published by Cold Spring Harbor Laboratory Press. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1101/gr.154492.113 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | COMPUTER SCIENCE | |
dc.description.doi | 10.1101/gr.154492.113 | |
dc.description.sourcetitle | Genome Research | |
dc.description.volume | 23 | |
dc.description.issue | 9 | |
dc.description.page | 1422-1433 | |
dc.description.coden | GEREF | |
dc.identifier.isiut | 000324080000006 | |
Appears in Collections: | Staff Publications |
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