Please use this identifier to cite or link to this item: https://doi.org/10.1167/iovs.13-13315
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dc.titleMeasurement of macular fractal dimension using a computer-assisted program
dc.contributor.authorThomas, G.N.
dc.contributor.authorOng, S.-Y.
dc.contributor.authorTham, Y.C.
dc.contributor.authorHsu, W.
dc.contributor.authorLee, M.L.
dc.contributor.authorLau, Q.P.
dc.contributor.authorTay, W.
dc.contributor.authorAlessi-Calandro, J.
dc.contributor.authorHodgson, L.
dc.contributor.authorKawasaki, R.
dc.contributor.authorWong, T.Y.
dc.contributor.authorCheung, C.Y.
dc.date.accessioned2014-07-04T03:09:55Z
dc.date.available2014-07-04T03:09:55Z
dc.date.issued2014-02-13
dc.identifier.citationThomas, G.N., Ong, S.-Y., Tham, Y.C., Hsu, W., Lee, M.L., Lau, Q.P., Tay, W., Alessi-Calandro, J., Hodgson, L., Kawasaki, R., Wong, T.Y., Cheung, C.Y. (2014-02-13). Measurement of macular fractal dimension using a computer-assisted program. Investigative Ophthalmology and Visual Science 55 (4) : 2237-2243. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.13-13315
dc.identifier.issn15525783
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77884
dc.description.abstractPurpose. Macular diseases may be associated with an altered retinal vasculature. We describe and test new software for the measurement of retinal vascular fractal dimension to quantify the complexity of retinal vasculature at the macula (Dmac) and to compare this with fractal dimension measured around the optic disc (Ddisc). Methods. A total of 342 macular-centered and optic disc-centered digital retinal photographs from 171 subjects was selected randomly from a population-based study. Retinal vascular fractional dimension (Df) was measured by two trained graders using a computer-assisted program (SIVA-FA, software version 1.0, National University of Singapore) on macula-centered (Dmac) and optic disc-centered (Ddisc) photographs, to assess intergrader reliability. Measurements were repeated after two weeks to determine intragrader reliability. A separate 50 pairs of consecutively repeated images were selected and measured using SIVA-FA to assess intrasession reliability. Reliability analyses were conducted using intraclass correlation coefficients (ICC), and multiple linear regression analyses were performed to compare factors associated with Dmacand Ddisc measurements.Results. The mean (SD) Dmac and Ddisc values were 1.453 (0.060) and 1.484 (0.043), respectively, and were highly correlated (r = 0.70, P < 0.001). Intragrader, intergrader, and intrasession reliability for both Df measures was high (ICCs ranging from 0.88-0.99). In multiple regression analyses, age (both β = -0.03, P < 0.001) and hypertension (β = -0.02, P = 0.011; β = -0.02, P = 0.021, respectively) were independently associated with Dmac and Ddisc. Conclusions. The complexity of the retinal vasculature in the macula can be measured reliably and may be a useful tool to study parafoveal vascular networks in macula diseases, such as diabetic maculopathy. © 2014 The Association for Research in Vision and Ophthalmology, Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.13-13315
dc.sourceScopus
dc.subjectFractal
dc.subjectMacula
dc.subjectRetinal vasculature
dc.typeArticle
dc.contributor.departmentCOMPUTER SCIENCE
dc.contributor.departmentOPHTHALMOLOGY
dc.description.doi10.1167/iovs.13-13315
dc.description.sourcetitleInvestigative Ophthalmology and Visual Science
dc.description.volume55
dc.description.issue4
dc.description.page2237-2243
dc.description.codenIOVSD
dc.identifier.isiut000335913100029
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