Please use this identifier to cite or link to this item: https://doi.org/10.1186/gb-2012-13-10-R82
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dc.titleBatMeth: improved mapper for bisulfite sequencing reads on DNA methylation
dc.contributor.authorLim, J.-Q.
dc.contributor.authorTennakoon, C.
dc.contributor.authorLi, G.
dc.contributor.authorWong, E.
dc.contributor.authorRuan, Y.
dc.contributor.authorWei, C.-L.
dc.contributor.authorSung, W.-K.
dc.date.accessioned2014-07-04T03:09:14Z
dc.date.available2014-07-04T03:09:14Z
dc.date.issued2012-03-10
dc.identifier.citationLim, J.-Q., Tennakoon, C., Li, G., Wong, E., Ruan, Y., Wei, C.-L., Sung, W.-K. (2012-03-10). BatMeth: improved mapper for bisulfite sequencing reads on DNA methylation. Genome Biology 13 (10) : -. ScholarBank@NUS Repository. https://doi.org/10.1186/gb-2012-13-10-R82
dc.identifier.issn1474760X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77828
dc.description.abstractDNA methylation plays a crucial role in higher organisms. Coupling bisulfite treatment with next generation sequencing enables the interrogation of 5-methylcytosine sites in the genome. However, bisulfite conversion introduces mismatches between the reads and the reference genome, which makes mapping of Illumina and SOLiD reads slow and inaccurate. BatMeth is an algorithm that integrates novel Mismatch Counting, List Filtering, Mismatch Stage Filtering and Fast Mapping onto Two Indexes components to improve unique mapping rate, speed and precision. Experimental results show that BatMeth is faster and more accurate than existing tools. BatMeth is freely available at http://code.google.com/p/batmeth/. © 2012 Lim et al.; licensee BioMed Central Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1186/gb-2012-13-10-R82
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCOMPUTER SCIENCE
dc.description.doi10.1186/gb-2012-13-10-R82
dc.description.sourcetitleGenome Biology
dc.description.volume13
dc.description.issue10
dc.description.page-
dc.description.codenGNBLF
dc.identifier.isiut000313183900001
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