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Title: Diversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach
Authors: Kang, N.-Y.
Ha, H.-H. 
Yun, S.-W.
Yu, Y.H. 
Chang, Y.-T. 
Issue Date: Jul-2011
Citation: Kang, N.-Y., Ha, H.-H., Yun, S.-W., Yu, Y.H., Chang, Y.-T. (2011-07). Diversity-driven chemical probe development for biomolecules: Beyond hypothesis-driven approach. Chemical Society Reviews 40 (7) : 3613-3626. ScholarBank@NUS Repository.
Abstract: Bioprobes are indispensable tools for biological study and clinical diagnosis. A conventional strategy for probe development is hypothesis-driven approach based on known molecular mechanisms of recognition for individual analytes. However, even the most sophisticated rational design does not always guarantee the applicability of probes in complex biological systems, therefore the efficiency and scope of probe development has been intrinsically limited. Diversity-driven approach is a rapidly emerging alternative and has been employed for the development of new probes even in the absence of the knowledge about target recognition mechanism. This tutorial review summarizes the recent advances in probe development along with conceptual advantages and perspectives of the diversity-driven approach. © 2011 The Royal Society of Chemistry.
Source Title: Chemical Society Reviews
ISSN: 03060012
DOI: 10.1039/c0cs00172d
Appears in Collections:Staff Publications

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