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|Title:||Transcription inhibition by organometallic rutheniumarene anticancer complexes in live mammalian cells||Authors:||Astarina, A.
|Issue Date:||2012||Citation:||Astarina, A., Chow, M.J., Ang, W.H. (2012). Transcription inhibition by organometallic rutheniumarene anticancer complexes in live mammalian cells. Australian Journal of Chemistry 65 (9) : 1271-1276. ScholarBank@NUS Repository. https://doi.org/10.1071/CH12059||Abstract:||Organometallic rutheniumarene RAPTA complexes, currently being actively pursued as potential anticancer agents, interact with intracellular biological targets to form covalent adducts. Because their mode of action is still unclear, we investigated their binding with DNA and the ability of ruthenated-DNA adducts to elicit cellular responses such as transcription inhibition and repair. To investigate the influence of the spectator arene ligands on RAPTA activity, a novel RAPTA complex containing the bulky 1,3,5-triisopropylbenzene ligand was synthesized and characterized. Transcription experiments carried out in live mammalian cells using ruthenated plasmid probes revealed that increasing steric bulk of the arene ligand did not improve its ability to arrest transcription. © 2012 CSIRO.||Source Title:||Australian Journal of Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/77499||ISSN:||00049425||DOI:||10.1071/CH12059|
|Appears in Collections:||Staff Publications|
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