Please use this identifier to cite or link to this item: https://doi.org/10.1071/CH09153
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dc.titleNovel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction
dc.contributor.authorLee, J.W.
dc.contributor.authorBork, J.T.
dc.contributor.authorHa, H.-H.
dc.contributor.authorSamanta, A.
dc.contributor.authorChang, Y.-T.
dc.date.accessioned2014-06-23T05:55:30Z
dc.date.available2014-06-23T05:55:30Z
dc.date.issued2009
dc.identifier.citationLee, J.W., Bork, J.T., Ha, H.-H., Samanta, A., Chang, Y.-T. (2009). Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction. Australian Journal of Chemistry 62 (9) : 1000-1006. ScholarBank@NUS Repository. https://doi.org/10.1071/CH09153
dc.identifier.issn00049425
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77472
dc.description.abstractTo expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the CC bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. © CSIRO 2009.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1071/CH09153
dc.sourceScopus
dc.typeConference Paper
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1071/CH09153
dc.description.sourcetitleAustralian Journal of Chemistry
dc.description.volume62
dc.description.issue9
dc.description.page1000-1006
dc.description.codenAJCHA
dc.identifier.isiut000269853200009
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