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|Title:||Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction||Authors:||Lee, J.W.
|Issue Date:||2009||Citation:||Lee, J.W., Bork, J.T., Ha, H.-H., Samanta, A., Chang, Y.-T. (2009). Novel orthogonal synthesis of a tagged combinatorial triazine library via grignard reaction. Australian Journal of Chemistry 62 (9) : 1000-1006. ScholarBank@NUS Repository. https://doi.org/10.1071/CH09153||Abstract:||To expand the diversity of 1,3,5-triazine libraries to aryl and alkyl functionalities through the CC bond, we employed a novel orthogonal synthesis via Grignard monoalkylation or monoarylation of cyanuric chloride in solution to prepare aryl- or alkyl-substituted triazine building blocks. These aryl- or alkyl-substituted triazine building blocks were captured by a resin-bound amine, followed by amination and acidic cleavage with high purity. Herein, we demonstrate a novel orthogonal synthesis of a tagged aryl- and alkyl-triazine library on solid support, utilizing building blocks prepared via Grignard reaction in solution. Through incorporation of a triethylene glycol linker at one of the alternate sites on the triazine scaffold we explored an intrinsic tagged library approach. © CSIRO 2009.||Source Title:||Australian Journal of Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/77472||ISSN:||00049425||DOI:||10.1071/CH09153|
|Appears in Collections:||Staff Publications|
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