Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(03)00942-7
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dc.titleAnalysis of Chinese medicine preparations by capillary electrophoresis- mass spectrometry
dc.contributor.authorFeng, H.-T.
dc.contributor.authorYuan, L.-L.
dc.contributor.authorLi, S.F.Y.
dc.date.accessioned2014-06-23T05:54:32Z
dc.date.available2014-06-23T05:54:32Z
dc.date.issued2003-10-03
dc.identifier.citationFeng, H.-T., Yuan, L.-L., Li, S.F.Y. (2003-10-03). Analysis of Chinese medicine preparations by capillary electrophoresis- mass spectrometry. Journal of Chromatography A 1014 (1-2) : 83-91. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(03)00942-7
dc.identifier.issn00219673
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77397
dc.description.abstractIn Chinese medicines, herbs are usually prepared before use by patients. Since the preparation procedures convert the original component into one or more products, study of the procedures is usually complex and involves several compounds. On-line coupling of capillary electrophoresis (CE) to mass spectrometry (MS) allows both the efficient separation of CE and the specific and sensitive detection of MS to be achieved. In this study, CE-MS was applied to the determination of alkaloids in Maqianzi (the seed of Strychnos pierrian) and Wutou (aconite root, Radix aconiti praeparata) during the preparation procedure. With optimal CE-MS conditions, alkaloids in both prepared and unprepared Maqianzi were determined successfully in the total ion current (TIC) mode. However, single ion monitoring (SIM) had to be applied for the separation of aconitum alkaloids and their hydrolysis products. Quantification data indicated that MS detection under SIM mode is more sensitive than UV detection. Based on the CE-MS method developed, the hydrolysis of aconitum alkaloids in water and methanol was also studied. © 2003 Published by Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0021-9673(03)00942-7
dc.sourceScopus
dc.subjectAconite roots
dc.subjectAlkaloids
dc.subjectPharmaceutical analysis
dc.subjectPlant materials
dc.subjectStrychnos pierrian
dc.typeConference Paper
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/S0021-9673(03)00942-7
dc.description.sourcetitleJournal of Chromatography A
dc.description.volume1014
dc.description.issue1-2
dc.description.page83-91
dc.description.codenJCRAE
dc.identifier.isiut000185557200009
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