Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmc.2010.07.068
Title: Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase
Authors: Ching, S.M.
Tan, W.J.
Chua, K.L.
Lam, Y. 
Keywords: Cyclic di-nucleotidic acid
Diguanylate cyclase
Inhibitor
Issue Date: 15-Sep-2010
Citation: Ching, S.M., Tan, W.J., Chua, K.L., Lam, Y. (2010-09-15). Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase. Bioorganic and Medicinal Chemistry 18 (18) : 6657-6665. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmc.2010.07.068
Abstract: Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. © 2010 Elsevier Ltd. All rights reserved.
Source Title: Bioorganic and Medicinal Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/77178
ISSN: 09680896
DOI: 10.1016/j.bmc.2010.07.068
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