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https://doi.org/10.1016/j.bmc.2010.07.068
Title: | Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase | Authors: | Ching, S.M. Tan, W.J. Chua, K.L. Lam, Y. |
Keywords: | Cyclic di-nucleotidic acid Diguanylate cyclase Inhibitor |
Issue Date: | 15-Sep-2010 | Citation: | Ching, S.M., Tan, W.J., Chua, K.L., Lam, Y. (2010-09-15). Synthesis of cyclic di-nucleotidic acids as potential inhibitors targeting diguanylate cyclase. Bioorganic and Medicinal Chemistry 18 (18) : 6657-6665. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmc.2010.07.068 | Abstract: | Five analogs of cyclic di-nucleotidic acid including c-di-GMP were synthesized and evaluated for their biological activities on Slr1143, a diguanylate cyclase of Synechocystis sp. Slr1143 was overexpressed from the recombinant plasmid which contained the gene of interest and subsequently purified by affinity chromatography. A new HPLC method capable of separating the compound and product peaks with good resolution was optimized and applied to the analysis of the compounds. Results obtained show that cyclic di-inosinylic acid 1b demonstrates a stronger inhibition on Slr1143 than c-di-GMP and is a potential inhibitor for biofilm formation. © 2010 Elsevier Ltd. All rights reserved. | Source Title: | Bioorganic and Medicinal Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/77178 | ISSN: | 09680896 | DOI: | 10.1016/j.bmc.2010.07.068 |
Appears in Collections: | Staff Publications |
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