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https://doi.org/10.1016/j.tetlet.2012.03.071
| Title: | Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins | Authors: | Ghosh, S.K. Butler, M.S. Lear, M.J. |
Keywords: | Antibiotic Dudley Enantiodivergent Erythritol Malaria Mevalonate Microbial Parasitic Sharpless Tetraols Threitol |
Issue Date: | 30-May-2012 | Citation: | Ghosh, S.K., Butler, M.S., Lear, M.J. (2012-05-30). Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters 53 (22) : 2706-2708. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2012.03.071 | Abstract: | The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway. © 2012 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/77169 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2012.03.071 |
| Appears in Collections: | Staff Publications |
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