Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2012.03.071
Title: Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins
Authors: Ghosh, S.K.
Butler, M.S.
Lear, M.J. 
Keywords: Antibiotic
Dudley
Enantiodivergent
Erythritol
Malaria
Mevalonate
Microbial
Parasitic
Sharpless
Tetraols
Threitol
Issue Date: 30-May-2012
Citation: Ghosh, S.K., Butler, M.S., Lear, M.J. (2012-05-30). Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins. Tetrahedron Letters 53 (22) : 2706-2708. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2012.03.071
Abstract: The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway. © 2012 Elsevier Ltd. All rights reserved.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/77169
ISSN: 00404039
DOI: 10.1016/j.tetlet.2012.03.071
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