Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2008.01.017
DC FieldValue
dc.titleSynthesis and anticancer activity studies of cyclopamine derivatives
dc.contributor.authorZhang, J.
dc.contributor.authorGarrossian, M.
dc.contributor.authorGardner, D.
dc.contributor.authorGarrossian, A.
dc.contributor.authorChang, Y.-T.
dc.contributor.authorKim, Y.K.
dc.contributor.authorChang, C.-W.T.
dc.date.accessioned2014-06-23T05:51:13Z
dc.date.available2014-06-23T05:51:13Z
dc.date.issued2008-02-15
dc.identifier.citationZhang, J., Garrossian, M., Gardner, D., Garrossian, A., Chang, Y.-T., Kim, Y.K., Chang, C.-W.T. (2008-02-15). Synthesis and anticancer activity studies of cyclopamine derivatives. Bioorganic and Medicinal Chemistry Letters 18 (4) : 1359-1363. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2008.01.017
dc.identifier.issn0960894X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/77126
dc.description.abstractA diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine. © 2008 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bmcl.2008.01.017
dc.sourceScopus
dc.subjectBioconjugates
dc.subjectCarbohydrates
dc.subjectCyclopamine
dc.subjectHedgehog pathway
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.bmcl.2008.01.017
dc.description.sourcetitleBioorganic and Medicinal Chemistry Letters
dc.description.volume18
dc.description.issue4
dc.description.page1359-1363
dc.description.codenBMCLE
dc.identifier.isiut000254180000021
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