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https://doi.org/10.1016/j.bmcl.2008.01.017
| Title: | Synthesis and anticancer activity studies of cyclopamine derivatives | Authors: | Zhang, J. Garrossian, M. Gardner, D. Garrossian, A. Chang, Y.-T. Kim, Y.K. Chang, C.-W.T. |
Keywords: | Bioconjugates Carbohydrates Cyclopamine Hedgehog pathway |
Issue Date: | 15-Feb-2008 | Citation: | Zhang, J., Garrossian, M., Gardner, D., Garrossian, A., Chang, Y.-T., Kim, Y.K., Chang, C.-W.T. (2008-02-15). Synthesis and anticancer activity studies of cyclopamine derivatives. Bioorganic and Medicinal Chemistry Letters 18 (4) : 1359-1363. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2008.01.017 | Abstract: | A diversity-oriented synthesis has been developed for facile construction of a library of carbohydrate-cyclopamine conjugates. The synthetic protocol is suitable for generating cyclopamine derivatives with various structural motifs for exploring the desired activity. From this initial library, we have observed one derivative that exhibits improved activity against lung cancer cell as compared to cyclopamine. © 2008 Elsevier Ltd. All rights reserved. | Source Title: | Bioorganic and Medicinal Chemistry Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/77126 | ISSN: | 0960894X | DOI: | 10.1016/j.bmcl.2008.01.017 |
| Appears in Collections: | Staff Publications |
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