Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases

Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol800575z

Title:	Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases
Authors:	Yang, P.-Y. Wu, H. Lee, M.Y. Xu, A. Srinivasan, R. Yao, S.Q.
Issue Date:	15-May-2008
Citation:	Yang, P.-Y., Wu, H., Lee, M.Y., Xu, A., Srinivasan, R., Yao, S.Q. (2008-05-15). Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases. Organic Letters 10 (10) : 1881-1884. ScholarBank@NUS Repository. https://doi.org/10.1021/ol800575z
Abstract:	An efficient strategy for the solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases is described. The method is highlighted by its compatibility with readily available building blocks, as well as its ability to accommodate different functional groups. A 249-member library has thus far been successfully synthesized, characterized, and screened against Caspase-1, -3 and -7. © 2008 American Chemical Society.
Source Title:	Organic Letters
URI:	http://scholarbank.nus.edu.sg/handle/10635/77010
ISSN:	15237060
DOI:	10.1021/ol800575z
Appears in Collections:	Staff Publications

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