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https://doi.org/10.1016/S0040-4039(00)02199-7
Title: | Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives | Authors: | Lee, C.L. Chan, K.P. Lam, Y. Lee, S.Y. |
Keywords: | 1,4-Benzothiazin-3(4H)-one 1,4-Benzoxazin-3(4H)-one Solid-phase synthesis |
Issue Date: | 5-Feb-2001 | Citation: | Lee, C.L., Chan, K.P., Lam, Y., Lee, S.Y. (2001-02-05). Solid-phase combinatorial synthesis of 1,4-benzoxazin-3(4H)-one and 1,4-benzothiazin-3(4H)-one derivatives. Tetrahedron Letters 42 (6) : 1167-1169. ScholarBank@NUS Repository. https://doi.org/10.1016/S0040-4039(00)02199-7 | Abstract: | The first solid-phase synthesis of 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones is reported. Alkylation of the immobilized 4-hydroxy-3-nitrobenzamide (2a) and 3-nitro-4-sulfanylbenzamide (2b), followed by reduction and cyclization gave 4. Further alkylation and acylation in the presence of sodium hydride followed by TFA cleavage gave the desired 1,4-benzothiazin-3(4H)-ones and 1,4-benzoxazin-3(4H)-ones. © 2001 Elsevier Science Ltd. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/77007 | ISSN: | 00404039 | DOI: | 10.1016/S0040-4039(00)02199-7 |
Appears in Collections: | Staff Publications |
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