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|Title:||Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand||Authors:||Pagano, N.
|Issue Date:||2007||Citation:||Pagano, N., Maksimoska, J., Bregman, H., Williams, D.S., Webster, R.D., Xue, F., Meggers, E. (2007). Ruthenium half-sandwich complexes as protein kinase inhibitors: Derivatization of the pyridocarbazole pharmacophore ligand. Organic and Biomolecular Chemistry 5 (8) : 1218-1227. ScholarBank@NUS Repository. https://doi.org/10.1039/b700433h||Abstract:||A general route to ruthenium pyridocarbazole half-sandwich complexes is presented and applied to the synthesis of sixteen new compounds, many of which have modulated protein kinase inhibition properties. For example, the incorporation of a fluorine into the pyridine moiety increases the binding affinity for glycogen synthase kinase 3 by almost one order of magnitude. These data are supplemented with cyclic voltammetry experiments and a protein co-crystallographic study. © The Royal Society of Chemistry.||Source Title:||Organic and Biomolecular Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/76914||ISSN:||14770520||DOI:||10.1039/b700433h|
|Appears in Collections:||Staff Publications|
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