Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol061431a
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dc.titleRapid assembly of matrix metalloprotease inhibitors using click chemistry
dc.contributor.authorWang, J.
dc.contributor.authorUttamchandani, M.
dc.contributor.authorLi, J.
dc.contributor.authorHu, M.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-06-23T05:47:53Z
dc.date.available2014-06-23T05:47:53Z
dc.date.issued2006-08-17
dc.identifier.citationWang, J., Uttamchandani, M., Li, J., Hu, M., Yao, S.Q. (2006-08-17). Rapid assembly of matrix metalloprotease inhibitors using click chemistry. Organic Letters 8 (17) : 3821-3824. ScholarBank@NUS Repository. https://doi.org/10.1021/ol061431a
dc.identifier.issn15237060
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76853
dc.description.abstractA panel of 96 metalloprotease inhibitors was assembled using "click chemistry" by reacting eight zinc-binding hydroxamate warheads with 12 azide building blocks. Screens of the bidentate compounds against representative metalloproteases provided discerning inhibition fingerprints, revealing compounds with low micromolar potency against MMP-7. The relative ease and convenience of the strategy in constructing focused chemical libraries for rapid in situ screening of MMPs is thereby demonstrated. © 2006 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ol061431a
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/ol061431a
dc.description.sourcetitleOrganic Letters
dc.description.volume8
dc.description.issue17
dc.description.page3821-3824
dc.identifier.isiut000239655500051
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