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https://doi.org/10.1016/0142-9612(95)00317-7
Title: | Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets | Authors: | Khor, E. Tay, L.F. Goh, K.S. Lee, C.N. |
Keywords: | Drug delivery Endocarditis Gentamicin Prosthetic heart valves |
Issue Date: | Aug-1996 | Citation: | Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7 | Abstract: | A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability. | Source Title: | Biomaterials | URI: | http://scholarbank.nus.edu.sg/handle/10635/76816 | ISSN: | 01429612 | DOI: | 10.1016/0142-9612(95)00317-7 |
Appears in Collections: | Staff Publications |
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