Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets

Please use this identifier to cite or link to this item: https://doi.org/10.1016/0142-9612(95)00317-7

Title:	Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets
Authors:	Khor, E. Tay, L.F. Goh, K.S. Lee, C.N.
Keywords:	Drug delivery Endocarditis Gentamicin Prosthetic heart valves
Issue Date:	Aug-1996
Citation:	Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7
Abstract:	A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.
Source Title:	Biomaterials
URI:	http://scholarbank.nus.edu.sg/handle/10635/76816
ISSN:	01429612
DOI:	10.1016/0142-9612(95)00317-7
Appears in Collections:	Staff Publications

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