Please use this identifier to cite or link to this item:
|Title:||Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets||Authors:||Khor, E.
Prosthetic heart valves
|Issue Date:||Aug-1996||Citation:||Khor, E., Tay, L.F., Goh, K.S., Lee, C.N. (1996-08). Prevention of prosthetic valve endocarditis by impregnation of gentamicin into surgical pledgets. Biomaterials 17 (16) : 1631-1637. ScholarBank@NUS Repository. https://doi.org/10.1016/0142-9612(95)00317-7||Abstract:||A novel drug delivery system was developed for the treatment of prosthetic valve endocarditis (PVE). The antibiotic, gentamicin, was impregnated into surgical pledgets using non-solvent coacervation of polylactic acid (PLA) as a binding/encapsulating agent. The in vitro dissolution profiles show controlled release of gentamicin for up to 36 h when PLA of molecular weight 2000 is used and up to 7 d for PLA with a molecular weight of 50,000. The results indicate potential for the localized treatment of PVE, which is cost-effective, easy to manufacture and permits dosage variability.||Source Title:||Biomaterials||URI:||http://scholarbank.nus.edu.sg/handle/10635/76816||ISSN:||01429612||DOI:||10.1016/0142-9612(95)00317-7|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jan 17, 2020
WEB OF SCIENCETM
checked on Jan 9, 2020
checked on Dec 29, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.