Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201307803
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dc.titlePreparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains
dc.contributor.authorZhang, C.-J.
dc.contributor.authorTan, C.Y.J.
dc.contributor.authorGe, J.
dc.contributor.authorNa, Z.
dc.contributor.authorChen, G.Y.J.
dc.contributor.authorUttamchandani, M.
dc.contributor.authorSun, H.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-06-23T05:47:23Z
dc.date.available2014-06-23T05:47:23Z
dc.date.issued2013-12-23
dc.identifier.citationZhang, C.-J., Tan, C.Y.J., Ge, J., Na, Z., Chen, G.Y.J., Uttamchandani, M., Sun, H., Yao, S.Q. (2013-12-23). Preparation of small-molecule microarrays by trans-cyclooctene tetrazine ligation and their application in the high-throughput screening of protein-protein interaction inhibitors of bromodomains. Angewandte Chemie - International Edition 52 (52) : 14060-14064. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201307803
dc.identifier.issn14337851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76812
dc.description.abstractFast and efficient: A library of trans-cyclooctene (TCO)-modified small molecules were immobilized on tetrazine-functionalized glass slides by using the fastest bioorthogonal reaction known. The resulting small-molecule microarray was screened against a variety of human bromodomains to identify protein-protein interaction inhibitors. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.201307803
dc.sourceScopus
dc.subjectbioorthogonal chemistry
dc.subjectepigenetics
dc.subjectinhibitors
dc.subjectprotein-protein interactions
dc.subjectsmall-molecule microarrays
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1002/anie.201307803
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume52
dc.description.issue52
dc.description.page14060-14064
dc.description.codenACIEF
dc.identifier.isiut000328531100030
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