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Title: Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae)
Authors: Cao, S.-G.
Sng, V.H.L.
Wu, X.-H.
Sim, K.-Y. 
Tan, B.H.K.
Pereira, J.T.
Goh, S.H. 
Issue Date: 3-Sep-1998
Citation: Cao, S.-G.,Sng, V.H.L.,Wu, X.-H.,Sim, K.-Y.,Tan, B.H.K.,Pereira, J.T.,Goh, S.H. (1998-09-03). Novel cytotoxic polyprenylated xanthonoids from Garcinia gaudichaudii (Guttiferae). Tetrahedron 54 (36) : 10915-10924. ScholarBank@NUS Repository.
Abstract: Cytotoxicity guided phytochemical analysis of the leaf extract of the Malaysian medicinal plant Garcinia gaudichaudii led to the isolation of 15 novel cytotoxic compounds, gaudichaudiones A - H (1, 2, 8 - 10 and 12), gaudichaudiic acids A - E (3 - 6), including the known morellic acid (7) and forbesione (11). All are mainly tetraprenylated xanthonoids but gaudichaudione H (12) is a novel bridgehead methoxylated triprenylated xanthonoid. The novel caged structures were determined by detailed NMR spectral analysis and the compounds were found to exhibit significant cytotoxicity against several cancer cell lines.
Source Title: Tetrahedron
ISSN: 00404020
Appears in Collections:Staff Publications

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