Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2nr32196c
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dc.titleGold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy
dc.contributor.authorZhao, T.
dc.contributor.authorShen, X.
dc.contributor.authorLi, L.
dc.contributor.authorGuan, Z.
dc.contributor.authorGao, N.
dc.contributor.authorYuan, P.
dc.contributor.authorYao, S.Q.
dc.contributor.authorXu, Q.-H.
dc.contributor.authorXu, G.Q.
dc.date.accessioned2014-06-23T05:40:28Z
dc.date.available2014-06-23T05:40:28Z
dc.date.issued2012
dc.identifier.citationZhao, T., Shen, X., Li, L., Guan, Z., Gao, N., Yuan, P., Yao, S.Q., Xu, Q.-H., Xu, G.Q. (2012). Gold nanorods as dual photo-sensitizing and imaging agents for two-photon photodynamic therapy. Nanoscale 4 (24) : 7712-7719. ScholarBank@NUS Repository. https://doi.org/10.1039/c2nr32196c
dc.identifier.issn20403364
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76252
dc.description.abstractGold nanorods with three different aspect ratios were prepared and their dual capabilities for two-photon imaging and two-photon photodynamic therapy have been demonstrated. These gold nanorods exhibit large two-photon absorption action cross-sections, about two orders of magnitude larger than small organic molecules, which makes them suitable for two-photon imaging. They can also effectively generate singlet oxygen under two-photon excitation, significantly higher than traditional photosensitizers such as Rose Bengal and Indocyanine Green. Such high singlet oxygen generation capability under two-photon excitation was ascribed to their large two-photon absorption cross-sections. Polyvinylpyrrolidone (PVP) coated gold nanorods displayed excellent biocompatibility and high cellular uptake efficiency. The two-photon photodynamic therapy effect and two-photon fluorescence imaging properties of PVP coated gold nanorods have been successfully demonstrated on HeLa cells in vitro using fluorescence microscopy and indirect XTT assay method. These gold nanorods thus hold great promise for imaging guided two-photon photodynamic therapy for the treatment of various malignant tumors. This journal is © 2012 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c2nr32196c
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1039/c2nr32196c
dc.description.sourcetitleNanoscale
dc.description.volume4
dc.description.issue24
dc.description.page7712-7719
dc.identifier.isiut000311641500016
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