Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.200903747
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dc.titleFunctional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites
dc.contributor.authorLiu, K.
dc.contributor.authorShi, H.
dc.contributor.authorXiao, H.
dc.contributor.authorChong, A.G.L.
dc.contributor.authorBi, X.
dc.contributor.authorChang, Y.-T.
dc.contributor.authorTan, K.S.W.
dc.contributor.authorYada, R.Y.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-06-23T05:40:09Z
dc.date.available2014-06-23T05:40:09Z
dc.date.issued2009-10-19
dc.identifier.citationLiu, K., Shi, H., Xiao, H., Chong, A.G.L., Bi, X., Chang, Y.-T., Tan, K.S.W., Yada, R.Y., Yao, S.Q. (2009-10-19). Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites. Angewandte Chemie - International Edition 48 (44) : 8293-8297. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903747
dc.identifier.issn14337851
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/76228
dc.description.abstractProfile and eliminate! Plasmepsins (PMs), aspartic proteases required for malariaparasite growth, are promising antimalarial targets. The in situ screening of PMs with probes formed from β-hydroxyazides 1 and alkynes with a photo-cross-linking unit and a tetraethylrhodamine reporter led to the identification of the smallmolecule inhibitor 2, which inhibits all fourfood-vacuole PMs and showed potent antimalarial activity in red-blood-cell cultures. © 2009 Wiley-VCH Verlag GmbH S. Co. KCaA.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/anie.200903747
dc.sourceScopus
dc.subjectActivity-based profiling
dc.subjectAffinity-based profiling
dc.subjectChemical proteomics
dc.subjectClick chemistry
dc.subjectMalaria
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1002/anie.200903747
dc.description.sourcetitleAngewandte Chemie - International Edition
dc.description.volume48
dc.description.issue44
dc.description.page8293-8297
dc.description.codenACIEA
dc.identifier.isiut000271302900021
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