Please use this identifier to cite or link to this item: https://doi.org/10.1002/adsc.201100419
Title: Enantioselective synthesis of chromanones via a tryptophan-derived bifunctional thiourea-catalyzed oxa-Michael-Michael cascade reaction
Authors: Wang, H.
Luo, J.
Han, X.
Lu, Y. 
Keywords: bifunctional catalysts
cascade reactions
chromanones
chromans
tryptophan
Issue Date: Nov-2011
Citation: Wang, H., Luo, J., Han, X., Lu, Y. (2011-11). Enantioselective synthesis of chromanones via a tryptophan-derived bifunctional thiourea-catalyzed oxa-Michael-Michael cascade reaction. Advanced Synthesis and Catalysis 353 (16) : 2971-2975. ScholarBank@NUS Repository. https://doi.org/10.1002/adsc.201100419
Abstract: Tryptophan-derived tertiary amine-thiourea catalysts were shown to promote a cascade oxa-Michael-Michael reaction between ethylene β-keto esters and nitroolefins, resulting in the formation of 3,3-disubstituted 4-chromanones bearing a quaternary center in high diastereoselectivity and enantioselectivity. The chromanone products can be readily converted to biologically important fused and spiro tricyclic chromans. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Advanced Synthesis and Catalysis
URI: http://scholarbank.nus.edu.sg/handle/10635/76109
ISSN: 16154150
DOI: 10.1002/adsc.201100419
Appears in Collections:Staff Publications

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