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https://doi.org/10.3390/ma4101728
DC Field | Value | |
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dc.title | Chitin-methacrylate: Preparation, characterization and hydrogel formation | |
dc.contributor.author | Khor, E. | |
dc.contributor.author | Wu, H. | |
dc.contributor.author | Lim, L.Y. | |
dc.contributor.author | Guo, C.M. | |
dc.date.accessioned | 2014-06-23T05:34:16Z | |
dc.date.available | 2014-06-23T05:34:16Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Khor, E., Wu, H., Lim, L.Y., Guo, C.M. (2011). Chitin-methacrylate: Preparation, characterization and hydrogel formation. Materials 4 (10) : 1728-1746. ScholarBank@NUS Repository. https://doi.org/10.3390/ma4101728 | |
dc.identifier.issn | 19961944 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/75756 | |
dc.description.abstract | Chitin-methacrylate (CM) was prepared by the reaction of methacrylic acid on chitin in 5% LiCl/DMAc in the presence of N,N'-dicyclocarbodiimide and dimethylaminopyridine. The resultant chitin-methacrylate product was isolated in 61% yield and was found to be readily water-soluble. The derivative was found to be a mixture of methacrylate and methacrylic-dimethylaminopyridine complex substituents at the C-6 position in approximately equal amounts. In order to evaluate the activity of the methacrylate double bond, a chitin-methacrylate water solution was photo-crosslinked in the presence of Irgacure 2959 photo-initiator to generate CM-hydrogel. The CM-hydrogel was evaluated for its biodegradability characteristics by enzymatic degradation with lysozyme solutions of varying concentrations. Completely water-soluble products were obtained within 48 h. In vitro cytotoxicity assays of the CM-hydrogel and its extract against three cell lines, NCTC clone 929, IMR-90 and MG-63, indicated the hydrogel was non-cytotoxic with cells able to adhere and proliferate well on the hydrogel. © 2011 by the authors. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3390/ma4101728 | |
dc.source | Scopus | |
dc.subject | Chitin derivatization | |
dc.subject | Chitin-methacrylate | |
dc.subject | Cytotoxicity | |
dc.subject | Degradation | |
dc.subject | Hydrogel | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.3390/ma4101728 | |
dc.description.sourcetitle | Materials | |
dc.description.volume | 4 | |
dc.description.issue | 10 | |
dc.description.page | 1728-1746 | |
dc.identifier.isiut | 000298246100005 | |
Appears in Collections: | Staff Publications |
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