Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3gc36966h
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dc.titleApplication of a recyclable fluorous oxime in the convenient synthesis of 3-amino-1,2-benzisoxazoles and 4-amino-1H-2,3-benzoxazines
dc.contributor.authorAng, W.J.
dc.contributor.authorChu, C.-Y.
dc.contributor.authorChou, T.-C.
dc.contributor.authorLo, L.-C.
dc.contributor.authorLam, Y.
dc.date.accessioned2014-06-23T05:32:16Z
dc.date.available2014-06-23T05:32:16Z
dc.date.issued2013-03
dc.identifier.citationAng, W.J., Chu, C.-Y., Chou, T.-C., Lo, L.-C., Lam, Y. (2013-03). Application of a recyclable fluorous oxime in the convenient synthesis of 3-amino-1,2-benzisoxazoles and 4-amino-1H-2,3-benzoxazines. Green Chemistry 15 (3) : 780-785. ScholarBank@NUS Repository. https://doi.org/10.1039/c3gc36966h
dc.identifier.issn14639262
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/75593
dc.description.abstractA microwave-assisted, fluorous synthetic route to 3-amino-1,2- benzisoxazoles and 4-amino-1H-2,3-benzoxazines has been developed. The strategy comprises linking the respective 2-fluorobenzonitrile or 2-(bromomethyl) benzonitrile to a fluorous oxime tag to give an aryloxime intermediate which then undergoes cyclization with concomitant cleavage of the substrate-tag in acidic conditions to provide the desired product in good to moderate yields. In addition, the aryloxime intermediate could be subjected to further reactions to expand the compound library. The product could be easily separated using fluorous solid-phase extraction (F-SPE) and the fluorous ketone recovered could be converted back to the fluorous oxime and reused in the next run of the synthesis. This journal is © 2013 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c3gc36966h
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1039/c3gc36966h
dc.description.sourcetitleGreen Chemistry
dc.description.volume15
dc.description.issue3
dc.description.page780-785
dc.description.codenGRCHF
dc.identifier.isiut000315356400030
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