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https://doi.org/10.1039/c000283f
| Title: | An unnatural amino acid that mimics phosphotyrosine | Authors: | Ge, J. Wu, H. Yao, S.Q. |
Issue Date: | 2010 | Citation: | Ge, J., Wu, H., Yao, S.Q. (2010). An unnatural amino acid that mimics phosphotyrosine. Chemical Communications 46 (17) : 2980-2982. ScholarBank@NUS Repository. https://doi.org/10.1039/c000283f | Abstract: | By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments. © The Royal Society of Chemistry 2010. | Source Title: | Chemical Communications | URI: | http://scholarbank.nus.edu.sg/handle/10635/75570 | ISSN: | 13597345 | DOI: | 10.1039/c000283f |
| Appears in Collections: | Staff Publications |
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