An efficient and expeditious synthesis of Di- And monosubstituted 2-aminoimidazoles

Abstract

A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(IH-imidazol-2-yl)acetamides from readily available α-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using commercially available parallel reactors. © 2008 American Chemical Society.