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|Title:||An efficient and expeditious synthesis of Di- And monosubstituted 2-aminoimidazoles||Authors:||Soh, C.H.
|Issue Date:||Jan-2008||Citation:||Soh, C.H., Chui, W.K., Lam, Y. (2008-01). An efficient and expeditious synthesis of Di- And monosubstituted 2-aminoimidazoles. Journal of Combinatorial Chemistry 10 (1) : 118-122. ScholarBank@NUS Repository. https://doi.org/10.1021/cc700143n||Abstract:||A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(IH-imidazol-2-yl)acetamides from readily available α-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using commercially available parallel reactors. © 2008 American Chemical Society.||Source Title:||Journal of Combinatorial Chemistry||URI:||http://scholarbank.nus.edu.sg/handle/10635/75557||ISSN:||15204766||DOI:||10.1021/cc700143n|
|Appears in Collections:||Staff Publications|
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